ABSTRACT
Background: SARS-CoV-2 enters the cell, by interacting with angiotensin-converting enzyme 2 (ACE-2) receptors, and affects a wide range of tissues and organs. Thus, ACE-2 receptors are found in placental tissues, as confirmed by the growing number of publications on the detection of virions in cotyledons. To date, the infectious involvement and localization of SARS-CoV-2 in placental tissue are described in a small series of cases and occur with a low frequency of 21%. The current data show that pregnant women infected with SARS-CoV-2 have a high risk of miscarriage, preeclampsia, preterm birth, and perinatal mortality. In view of the fact that constant efforts are being undertaken to study the placentas of patients who have experienced COVID-19 in order to further predict the effect of SARS-CoV-2 on pregnant women and newborns. Case report: This investigation analyzes data on three clinical cases of the course and outcomes pregnancy in patients after having experienced the novel coronavirus infection in early gestation. It presents in detail the nature of histopathological changes in placental tissue after SARS-CoV-2 infection. Conclusion: Based on the presented clinical cases, by comparing the findings and changes in the fetoplacental complex, there is an idea of its possible damage in pregnant women who have experienced SARS-CoV-2 infection in the early stages of gestation, regardless of the severity of the disease, as demonstrated by these clinical cases.